Gestational Diabetes Mellitus — SAQ 1

Stem

Named source links for threshold and regional answers: WHO diagnostic classification, NICE NG3, ADA 2026, and ACOG 2024.^[1][4][6]

A 33-year-old South Asian primigravida at 27 weeks undergoes a one-step fasting 75 g OGTT under the local WHO/IADPSG pathway. Plasma glucose is fasting 5.4 mmol/L, 1 hour 10.6 mmol/L and 2 hours 9.0 mmol/L. Her booking BMI was 31 kg/m². Fetal abdominal circumference is on the 55th centile. There is no documented glucose result meeting overt-diabetes thresholds.^[1]

Questions and model answer

a) State the diagnosis and apply the named criteria. (2 marks)

• 1 mark: GDM by the WHO/IADPSG one-step 75 g OGTT: any one value at or above fasting 5.1, 1 hour 10.0, or 2 hours 8.5 mmol/L is diagnostic; all three values are positive.^[1]
• 1 mark: Do not invent a normal booking HbA1c. First-detected fasting ≥7.0 or 2-hour 75 g ≥11.1 mmol/L would instead meet overt-diabetes thresholds under the WHO classification; absent unequivocal hyperglycaemia, confirm abnormal diabetes-range results.^[1]

b) Explain the maternal-to-fetal pathophysiology. (2 marks)

• 1 mark: Placental and maternal signals increase insulin resistance; GDM occurs when beta-cell secretion cannot increase enough to compensate, not because insulin output must absolutely fall.^[2]
• 1 mark: Maternal glucose crosses the placenta while maternal insulin ordinarily does not; fetal hyperglycaemia drives fetal insulin secretion, adiposity and excess growth, with hypoglycaemia risk after cord clamping.^[2]

c) Give the first management step and monitoring targets. (2 marks)

• 1 mark: Start individualised dietitian-supported nutrition that preserves adequate pregnancy nutrition and avoids ketosis, plus moderate activity such as about 30 minutes on most days if no obstetric contraindication.^[3][6]
• 1 mark: Teach fasting and post-meal capillary monitoring. ADA/ACOG targets are fasting <5.3, 1 hour <7.8 and 2 hours <6.7 mmol/L; NICE NG3 uses the same strict fasting/1-hour boundaries but 2 hours <6.4 mmol/L, if achievable without problematic hypoglycaemia.^[3][6]

d) After 2 weeks, repeated fasting and post-meal values remain above target. Contrast pharmacotherapy in the US and UK. (2 marks)

• 1 mark: ADA/ACOG practice prefers insulin as first-line pharmacotherapy. Select basal, mealtime or basal-bolus insulin from the glucose pattern; do not prescribe one universal dose. Metformin and glyburide cross the placenta and are not preferred first line. ADA 2026 advises avoiding metformin with hypertension/pre-eclampsia or fetal-growth-restriction/placental-insufficiency risk.^[3][6]
• 1 mark: NICE NG3 usually offers metformin when lifestyle has not met targets within 1 to 2 weeks, then insulin if metformin is contraindicated, unacceptable or inadequate. Immediate-insulin exceptions include fasting glucose ≥7.0 mmol/L, or consideration at 6.0–6.9 mmol/L with macrosomia or hydramnios.^[5]

e) Outline growth surveillance and birth planning if control remains good and growth stays normal. (2 marks)

• 1 mark: Keep growth assessment separate from fetal wellbeing testing: NICE NG3 offers growth/amniotic-fluid ultrasound at 28, 32 and 36 weeks; US medication-treated or poorly controlled disease commonly prompts antenatal testing from about 32 weeks, whereas well-controlled diet-only GDM has no consensus requirement.^[3]
• 1 mark: Birth timing is regional: NICE NG3 advises birth no later than 40+6 for uncomplicated GDM; ACOG well-controlled A1 not before 39 and expectant to 40+6, while well-controlled medication-treated GDM is usually 39+0 to 39+6. Complications require individualisation; EFW ≥4,500 g prompts counselling about scheduled caesarean, not an automatic operation.^[3]

Reproducible total: 2 + 2 + 2 + 2 + 2 = 10 marks.^[3]

References6ShowHide

1. [1]Metzger BE, Gabbe SG, Persson B, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy Diabetes Care, 2010.PMID 20190296
2. [2]Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers MH. The Pathophysiology of Gestational Diabetes Mellitus Int J Mol Sci, 2018.PMID 30373146
3. [3]ACOG. ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus Obstet Gynecol, 2018.PMID 29370047
4. [4]ACOG. ACOG Clinical Practice Update: Screening for Gestational and Pregestational Diabetes in Pregnancy and Postpartum Obstet Gynecol, 2024.PMID 42131962
5. [5]Rowan JA, Hague WM, Gao W, Battin MR, Moore MP. Metformin versus insulin for the treatment of gestational diabetes N Engl J Med, 2008.PMID 18463376
6. [6]American Diabetes Association Professional Practice Committee for Diabetes. 15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes—2026 Diabetes Care, 2026.PMID 41358885