Example 1 · difficulty 3/5
During replication in E. coli, the two antiparallel strands of the parental duplex are copied differently. The lagging strand is synthesised discontinuously as short Okazaki fragments primarily because
- A. helicase unwinds the duplex only ahead of the leading strand
- B. DNA ligase can seal nicks only between leading-strand segments
- C. RNA primers are synthesised exclusively on the lagging strand
- D. DNA-dependent DNA polymerase catalyses polymerisation only in the 5'→3' direction